MODO

gnm2 gnmvib1 kindom1 rigprof1

MODO is currently being set up. Its purpose is to identify regions that undergoe Rigid Body Motions in proteins. The project is a spin-off from work on the kinesin motor proteins, where we were motivated to get a better understanding of their behaviour, in molecular terms.

The Kinesin challenge was to provide some interpretation of the exceptional mechanical properties. We used two main approaches to investigave Kinesin's mechanical properties:

  1. a detailed approach using molecular dynamics, and
  2. a coarse-grained model.

The latter, called GNM (Gaussian Network Model), gave interesting results and motivated us to make a generic method available. More details about the methods used can be found here.


Last modified on Tue Sep 18 00:24:08 CEST 2007